For research use only. Not for therapeutic Use.
BSc5367 is a potent Nek1 inhibitor with an IC50 of 11.5 nM. NIMA-related protein kinase Nek1 is crucially involved in cell cycle regulation, DNA repair and microtubule regulation and dysfunctions of Nek1 play key roles in amyotrophic lateral sclerosis (ALS), polycystic kidney disease (PKD) and several types of radiotherapy resistant cancer[1].
| CAS Number | 3029584-84-4 |
| Synonyms | methyl 3-(3-pyridin-3-yl-1H-pyrrolo[2,3-b]pyridin-5-yl)benzoate |
| Molecular Formula | C20H15N3O2 |
| Purity | ≥95% |
| InChI | InChI=1S/C20H15N3O2/c1-25-20(24)14-5-2-4-13(8-14)16-9-17-18(12-23-19(17)22-11-16)15-6-3-7-21-10-15/h2-12H,1H3,(H,22,23) |
| InChIKey | GZHRICWZECSYJT-UHFFFAOYSA-N |
| SMILES | COC(=O)C1=CC=CC(=C1)C2=CC3=C(NC=C3C4=CN=CC=C4)N=C2 |
| Reference | [1]. Pilakowski J, et al. Design, synthesis and biological evaluation of novel aminopyrazole- and 7-azaindole-based Nek1 inhibitors and their effects on zebrafish kidney development. Bioorg Med Chem Lett. 2021;53:128418. |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
