For research use only. Not for therapeutic Use.
BSJ-03-204 (Cat No.: I023752) is a potent and selective CDK4/6 dual degrader (PROTAC) based on Palbociclib (HY-50767), with IC50 for CDK4/D1 and CDK6/D1, respectively are 26.9nM and 10.4nM. BSJ-03-204 does not induce IKZF1/3 degradation and has anticancer activity. If you need, please contact us in time, and we will reply to you as soon as possible within 24 hours.
| Catalog Number | I023752 |
| CAS Number | 2349356-09-6 |
| Synonyms | BSJ-03-204; BSJ03204; BSJ 03 204 |
| Molecular Formula | C43H48N10O8 |
| Purity | 98% |
| Target | Cell Cycle/DNA Damage |
| Solubility | Soluble in DMSO |
| Appearance | Solid powder |
| Storage | -20°C, protect from light |
| IUPAC Name | N-[4-[4-[6-[(6-Acetyl-8-cyclopentyl-7,8-dihydro-5-methyl-7-oxopyrido[2,3-d]pyrimidin-2-yl)amino]-3-pyridinyl]-1-piperazinyl]butyl]-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetamide |
| InChI | InChI=1S/C43H48N10O8/c1-25-30-23-46-43(49-38(30)52(27-8-3-4-9-27)41(59)36(25)26(2)54)47-33-14-12-28(22-45-33)51-20-18-50(19-21-51)17-6-5-16-44-35(56)24-61-32-11-7-10-29-37(32)42(60)53(40(29)58)31-13-15-34(55)48-39(31)57/h7,10-12,14,22-23,27,31H,3-6,8-9,13,15-21,24H2,1-2H3,(H,44,56)(H,48,55,57)(H,45,46,47,49) |
| InChIKey | KDMOCOWXLQOXEB-UHFFFAOYSA-N |
| SMILES | O=C(NCCCCN1CCN(C2=CC=C(NC3=NC=C(C(C)=C(C(C)=O)C(N4C5CCCC5)=O)C4=N3)N=C2)CC1)COC6=CC=CC(C(N7C(CC8)C(NC8=O)=O)=O)=C6C7=O |
| Reference | Jiang et al (2019) Development of dual and selective degraders of cyclin-dependent kinases 4 and 6. Angew.Chem.Int.Ed.Engl. 58 6321 PMID: 30802347 |
