For research use only. Not for therapeutic Use.
BSJ-04-122 is a covalent MKK4/7 dual inhibitor. BSJ-04-122 inhibits MKK4 and MKK7 with IC50 values of 4 nM and 181 nM, respectively. BSJ-04-122 can be used for the research of cancer[1].
BSJ-04-122 has inhibitory activity for MKK4 and MKK7 with IC50 values of 4 nM and 181 nM, respectively[1].
BSJ-04-122 (1, 5, 10 μM; 6 h) induces robust reduction of JNK phosphorylation[1].
BSJ-04-122 (0, 1.25, 2.5, 5, 10, 20 μM; 72 h) shows enhanced antiproliferative effects when combination with JNK-IN-8[1].
| Catalog Number | I042278 |
| CAS Number | 2513289-74-0 |
| Synonyms | N-[2-[(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]phenyl]prop-2-enamide |
| Molecular Formula | C15H12ClN5O |
| Purity | ≥95% |
| InChI | InChI=1S/C15H12ClN5O/c1-2-12(22)20-10-5-3-4-6-11(10)21-15-13-9(16)7-17-14(13)18-8-19-15/h2-8H,1H2,(H,20,22)(H2,17,18,19,21) |
| InChIKey | LWXOPXNDPRPGMJ-UHFFFAOYSA-N |
| SMILES | C=CC(=O)NC1=CC=CC=C1NC2=NC=NC3=C2C(=CN3)Cl |
| Reference | [1]. Jie Jiang, et al. Discovery of Covalent MKK4/7 Dual Inhibitor. Cell Chem Biol |
