For research use only. Not for therapeutic Use.
BSJ-04-132 (Cat.No:I023753) is a potent and selective inhibitor of the protein-protein interaction between BRD4 and chromatin. It exhibits potent anti-tumor activity in multiple cancer cell lines, including acute myeloid leukemia (AML), triple-negative breast cancer, and non-small cell lung cancer. In addition, BSJ-04-132 has shown to induce cell cycle arrest and apoptosis, making it a promising candidate for cancer therapy.
| Catalog Number | I023753 |
| CAS Number | 2349356-39-2 |
| Synonyms | BSJ-04-132; BSJ04132; BSJ 04 132; |
| Molecular Formula | C42H49N11O7 |
| Purity | 98% |
| Target | Cell Cycle/DNA Damage |
| Solubility | Soluble in DMSO |
| Appearance | Solid powder |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| IUPAC Name | 7-cyclopentyl-2-((5-(4-(4-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamido)butyl)piperazin-1-yl)pyridin-2-yl)amino)-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide |
| InChI | InChI=1S/C42H49N11O7/c1-49(2)40(58)31-22-26-23-45-42(48-37(26)52(31)27-8-3-4-9-27)46-33-14-12-28(24-44-33)51-20-18-50(19-21-51)17-6-5-16-43-35(55)25-60-32-11-7-10-29-36(32)41(59)53(39(29)57)30-13-15-34(54)47-38(30)56/h7,10-12,14,22-24,27,30H,3-6,8-9,13,15-21,25H2,1-2H3,(H,43,55)(H,47,54,56)(H,44,45,46,48) |
| InChIKey | GWLSXEHHNOBFOI-UHFFFAOYSA-N |
| SMILES | CN(C)C(=O)C1=CC2=CN=C(NC3=CC=C(C=N3)N3CCN(CCCCNC(=O)COC4=CC=CC5=C4C(=O)N(C4CCC(=O)NC4=O)C5=O)CC3)N=C2N1C1CCCC1 |
| Reference | 1. Angew. Chem. Int. Edit., 2019, 58, 6321-6326. (https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.201901336) |
