For research use only. Not for therapeutic Use.
BT173(CAT: I023756) is a potent and selective inhibitor of Homeodomain Interacting Protein Kinase 2 (HIPK2). Unlike traditional kinase inhibitors, BT173 does not block HIPK2’s catalytic activity but allosterically disrupts its interaction with Smad3. This unique mechanism interferes with the TGF-β1/Smad3 signaling pathway, leading to attenuation of renal fibrosis. BT173 is a valuable research tool for exploring fibrotic diseases and understanding non-canonical modulation of kinase function. Its specificity and novel mode of action make it ideal for studying HIPK2-related signaling mechanisms and developing targeted anti-fibrotic strategies.
| CAS Number | 2232180-74-2 |
| Synonyms | 3-(4-bromophenyl)-5-(7-methoxyquinolin-3-yl)-1,2,4-oxadiazole |
| Molecular Formula | C18H12BrN3O2 |
| Purity | ≥95% |
| IUPAC Name | 3-(4-bromophenyl)-5-(7-methoxyquinolin-3-yl)-1,2,4-oxadiazole |
| InChI | InChI=1S/C18H12BrN3O2/c1-23-15-7-4-12-8-13(10-20-16(12)9-15)18-21-17(22-24-18)11-2-5-14(19)6-3-11/h2-10H,1H3 |
| InChIKey | IZEKVHBNUXXZFE-UHFFFAOYSA-N |
| SMILES | COC1=CC2=NC=C(C=C2C=C1)C3=NC(=NO3)C4=CC=C(C=C4)Br |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
