For research use only. Not for therapeutic Use.
BT18 is a molecule mimic with function similar to glial cell line-derived neurotrophic factor (GDNF)[1]. BT18 shows an effect on GDNF family receptor GFRα1 and RET receptor tyrosine kinase RetA function[2].
BT18 (50 μM; 1-90 minutes) activates AKT and ERK1/2 in time-dependently in MG87RET cell lines[1].
BT18 (1-50 μM; 90 minutes) activates AKT in a dose-dependent manner in MG87RET cell lines[1].
BT18 (5-50 μM; 15 mimutes) appears to phosphorylate RET in concentration of 50 µM both in GFP-transfected and in GFRD1-transfected cells[1].
| Catalog Number | I019220 |
| CAS Number | 924811-53-0 |
| Synonyms | [4-[5-[(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)sulfonyl]-2-methoxyphenyl]piperazin-1-yl]-[4-fluoro-2-(trifluoromethyl)phenyl]methanone |
| Molecular Formula | C30H31F4N3O6S |
| Purity | ≥95% |
| InChI | InChI=1S/C30H31F4N3O6S/c1-41-26-7-5-22(44(39,40)37-9-8-19-14-27(42-2)28(43-3)15-20(19)18-37)17-25(26)35-10-12-36(13-11-35)29(38)23-6-4-21(31)16-24(23)30(32,33)34/h4-7,14-17H,8-13,18H2,1-3H3 |
| InChIKey | QVIIZVVDZZHGCB-UHFFFAOYSA-N |
| SMILES | COC1=C(C=C(C=C1)S(=O)(=O)N2CCC3=CC(=C(C=C3C2)OC)OC)N4CCN(CC4)C(=O)C5=C(C=C(C=C5)F)C(F)(F)F |
| Reference | [1]. Leo Jakman, Characterization of small-molecule GDNF mimics. [2]. Ivanova L, et al. Molecular Dynamics Simulations of the Interactions between Glial Cell Line-DerivedNeurotrophic Factor Family Receptor GFRα1 and Small-Molecule Ligands. ACS Omega. 2018 Sep 30;3(9):11407-11414. |
