For research use only. Not for therapeutic Use.
BTdCPU（Cat No.:I005135）is a selective inhibitor of casein kinase 1 delta and epsilon (CK1δ/ε), enzymes involved in regulating various cellular processes such as circadian rhythm, cell division, and DNA repair. By targeting CK1δ/ε, BTdCPU disrupts pathways associated with cancer cell proliferation, making it valuable in cancer research. Its selective inhibition provides insight into CK1’s role in oncogenesis and circadian biology, potentially aiding in the development of targeted cancer therapies and treatments for circadian-related disorders. BTdCPU is instrumental in studying kinase-related pathways, offering a unique approach to therapeutic exploration.
| Catalog Number | I005135 |
| CAS Number | 1257423-87-2 |
| Synonyms | BTdCPU;1-(Benzo[d][1,2,3]thiadiazol-6-yl)-3-(3,4-dichlorophenyl)urea |
| Molecular Formula | C13H8Cl2N4OS |
| Purity | ≥95% |
| Target | Apoptosis |
| Solubility | Soluble in DMSO |
| Storage | 0 - 4 °C for short term or -20 °C for long term |
| IUPAC Name | 1-(1,2,3-benzothiadiazol-6-yl)-3-(3,4-dichlorophenyl)urea |
| InChI | InChI=1S/C13H8Cl2N4OS/c14-9-3-1-7(5-10(9)15)16-13(20)17-8-2-4-11-12(6-8)21-19-18-11/h1-6H,(H2,16,17,20) |
| InChIKey | NUUSUAWULNXMGF-UHFFFAOYSA-N |
| SMILES | C1=CC2=C(C=C1NC(=O)NC3=CC(=C(C=C3)Cl)Cl)SN=N2 |
| Reference | </br>1: Burwick N, Zhang MY, de la Puente P, Azab AK, Hyun TS, Ruiz-Gutierrez M,</br> Sanchez-Bonilla M, Nakamura T, Delrow JJ, MacKay VL, Shimamura A. The eIF2-alpha </br> kinase HRI is a novel therapeutic target in multiple myeloma |
