BTK IN-1

• CAT Number: I013215
• CAS Number: 1270014-40-8
• Molecular Formula: C19H21ClN6O
• Molecular Weight: 384.86
• Purity: ≥95%
• Synonyms: 2-(3-chloroanilino)-N-[1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-3-yl]acetamide
• InChI: InChI=1S/C19H21ClN6O/c20-13-3-1-4-14(9-13)22-10-17(27)25-15-5-2-8-26(11-15)19-16-6-7-21-18(16)23-12-24-19/h1,3-4,6-7,9,12,15,22H,2,5,8,10-11H2,(H,25,27)(H,21,23,24)
• InChIKey: SPSNKQVUYDXOGY-UHFFFAOYSA-N
• SMILES: C1CC(CN(C1)C2=NC=NC3=C2C=CN3)NC(=O)CNC4=CC(=CC=C4)Cl

BTK IN-1 (SNS062 analog) is a potent BTK inhibitor, with an IC50 of <100 nM.
BTK IN-1 (Compound 21) is a potent BTK inhibitor, with an IC50 of <100 nM.

Reference

[1]. Minna Bui, et al. Heteroaryl btk inhibitors. WO2011029043A1