BTS

• CAT Number: I001999
• CAS Number: 1576-37-0
• Molecular Formula: C14H15NO2S
• Molecular Weight: 261.34
• Purity: ≥95%
• Target: Myosin
• Solubility: 10 mM in DMSO
• Storage: Room Temperature
• IC50: 5 uM
• IUPAC Name: N-benzyl-4-methylbenzenesulfonamide
• InChI: InChI=1S/C14H15NO2S/c1-12-7-9-14(10-8-12)18(16,17)15-11-13-5-3-2-4-6-13/h2-10,15H,11H2,1H3
• InChIKey: WTHKAJZQYNKTCJ-UHFFFAOYSA-N
• SMILES: CC1=CC=C(C=C1)S(=O)(=O)NCC2=CC=CC=C2

BTS (N-Benzyl-p-toluenesulfonamide) is a potent and selective inhibitor of skeletal muscle myosin II subfragment 1 (S1) ATPase activity, with IC50 for actin and Ca2+-stimulated myosin S1 ATPase The value is about 5 µM. BTS specifically inhibits the contraction of fast fibers of skeletal muscle.

Reference

[1]. Cheung A, et al. A small-molecule inhibitor of skeletal muscle myosin II. Nat Cell Biol. 2002 Jan;4(1):83-8.