BU 226 hydrochloride

• CAT Number: I010367
• CAS Number: 1186195-56-1
• Molecular Formula: C12H12ClN3
• Molecular Weight: 233.69
• Purity: ≥95%
• Synonyms: 2-(4,5-Dihydroimidazol-2-yl)isoquinoline hydrochloride
• Target: Imidazoline Receptor
• Solubility: Soluble to 100 mM in water
• Storage: Store at RT
• IUPAC Name: 3-(4,5-dihydro-1H-imidazol-2-yl)isoquinoline;hydrochloride
• InChI: InChI=1S/C12H11N3.ClH/c1-2-4-10-8-15-11(7-9(10)3-1)12-13-5-6-14-12;/h1-4,7-8H,5-6H2,(H,13,14);1H
• InChIKey: NIGHNKWLMSRCOZ-UHFFFAOYSA-N
• SMILES: C1CN=C(N1)C2=CC3=CC=CC=C3C=N2.Cl

BU 226 hydrochloride (Cat.No:I010367) is a selective agonist of the α7 nicotinic acetylcholine receptor (nAChR), which plays an important role in cognitive function, inflammation, and synaptic plasticity. It has been shown to improve cognitive performance in animal models and has potential therapeutic applications for Alzheimer’s disease and schizophrenia. BU 226 hydrochloride has an EC50 of 200 nM and exhibits selectivity for α7 nAChR over other subtypes.