Bucladesine calcium salt

• CAT Number: I005577
• CAS Number: 938448-87-4
• Molecular Formula: C18H23Ca0.5N5O8P
• Molecular Weight: 488.42
• Purity: ≥95%
• Target: PKA
• Solubility: Water 58 mg/ml
• Storage: 3 years -20C powder

Bucladesine calcium salt(CAT: I005577), also known as calcium di butyryl cyclic monophosphate (cAMP), is a cell-permeable analog of cyclic adenosine monophosphate (cAMP). It acts as a potent activator of protein kinase A (PKA) by mimicking the intracellular effects of endogenous cAMP. By activating PKA, bucladesine calcium salt regulates various cellular processes, including gene expression, cell proliferation, and differentiation. It is commonly used in research settings to study the intracellular signaling pathways mediated by cAMP and PKA. Additionally, bucladesine calcium salt has been investigated for its therapeutic potential in various disease conditions, such as cardiovascular disorders and neurological diseases.

Reference

[1]. Sharifzadeh, M., et al., Post-training intrahippocampal infusion of nicotine-bucladesine combination causes a synergistic enhancement effect on spatial memory retention in rats. Eur J Pharmacol, 2007. 562(3): p. 212-20. 


[2]. Azami, K., et al., The quantitative evaluation of cholinergic markers in spatial memory improvement induced by nicotine-bucladesine combination in rats. Eur J Pharmacol, 2010. 636(1-3): p. 102-7.


[3]. Mafune, E., M. Takahashi, and N. Takasugi, Effect of vehicles on percutaneous absorption of bucladesine (dibutyryl cyclic AMP) in normal and damaged rat skin. Biol Pharm Bull, 1995. 18(11): p. 1539-43.


[4]. Rundfeldt, C., et al., The stable cyclic adenosine monophosphate analogue, dibutyryl cyclo-adenosine monophosphate (bucladesine), is active in a model of acute skin inflammation. Arch Dermatol Res, 2012.