For research use only. Not for therapeutic Use.
Buclizine is an antihistamine and anticholinergic of the piperazine derivative family. It is considered to be an antiemetic, similar to meclizine.
| Catalog Number | I005173 |
| CAS Number | 129-74-8 (HCl) |
| Synonyms | AH 2526, AH-2526, AH2526; Buclizine; Buclizine dihydrochloride; UCB-4445, Buclina, Longifene, Posdel, Vibazine.;1-(4-(tert-butyl)benzyl)-4-((4-chlorophenyl)(phenyl)methyl)piperazine dihydrochloride |
| Molecular Formula | C28H35Cl3N2 |
| Purity | ≥95% |
| Target | Neuronal Signaling |
| Solubility | Soluble in DMSO, not in water |
| Storage | 0 - 4°C for short term ,or -20 °C for long term |
| IUPAC Name | 1-[(4-tert-butylphenyl)methyl]-4-[(4-chlorophenyl)-phenylmethyl]piperazine;dihydrochloride |
| InChI | InChI=1S/C28H33ClN2.2ClH/c1-28(2,3)25-13-9-22(10-14-25)21-30-17-19-31(20-18-30)27(23-7-5-4-6-8-23)24-11-15-26(29)16-12-24;;/h4-16,27H,17-21H2,1-3H3;2*1H |
| InChIKey | SDBHDSZKNVDKNU-UHFFFAOYSA-N |
| SMILES | CC(C)(C)C1=CC=C(C=C1)CN2CCN(CC2)C(C3=CC=CC=C3)C4=CC=C(C=C4)Cl.Cl.Cl |
| Reference | </br>1:Kuminek G, Stulzer HK, Tagliari MP, Oliveira PR, Bernardi LS, Rauber GS, Cardoso SG. </br> High-performance column liquid chromatographic method for the simultaneous determination of buclizine, tryptophan, pyridoxine, and cyanocobalamin in tablets and oral suspension. </br> J AOAC Int. 2011 Nov-Dec;94(6):1785-90. PubMed PMID: 22320085. |
