For research use only. Not for therapeutic Use.
Buclizine hydrochloride（Cat No.:I005173）is an antihistamine used to treat symptoms of motion sickness, nausea, and vomiting, as well as to manage allergic reactions such as hay fever and urticaria (hives). It works by blocking histamine receptors in the body, reducing the effects of histamine that can cause symptoms like swelling, itching, and inflammation. Buclizine also has mild sedative properties and can help alleviate dizziness and vertigo. It is commonly used in both over-the-counter and prescription medications, though it can cause side effects such as drowsiness, dry mouth, and blurred vision.
| Catalog Number | I005173 |
| CAS Number | 129-74-8 (HCl) |
| Synonyms | AH 2526, AH-2526, AH2526; Buclizine; Buclizine dihydrochloride; UCB-4445, Buclina, Longifene, Posdel, Vibazine.;1-(4-(tert-butyl)benzyl)-4-((4-chlorophenyl)(phenyl)methyl)piperazine dihydrochloride |
| Molecular Formula | C28H35Cl3N2 |
| Purity | ≥95% |
| Target | Neuronal Signaling |
| Solubility | Soluble in DMSO, not in water |
| Storage | 0 - 4°C for short term ,or -20 °C for long term |
| IUPAC Name | 1-[(4-tert-butylphenyl)methyl]-4-[(4-chlorophenyl)-phenylmethyl]piperazine;dihydrochloride |
| InChI | InChI=1S/C28H33ClN2.2ClH/c1-28(2,3)25-13-9-22(10-14-25)21-30-17-19-31(20-18-30)27(23-7-5-4-6-8-23)24-11-15-26(29)16-12-24;;/h4-16,27H,17-21H2,1-3H3;2*1H |
| InChIKey | SDBHDSZKNVDKNU-UHFFFAOYSA-N |
| SMILES | CC(C)(C)C1=CC=C(C=C1)CN2CCN(CC2)C(C3=CC=CC=C3)C4=CC=C(C=C4)Cl.Cl.Cl |
| Reference | </br>1:Kuminek G, Stulzer HK, Tagliari MP, Oliveira PR, Bernardi LS, Rauber GS, Cardoso SG. </br> High-performance column liquid chromatographic method for the simultaneous determination of buclizine, tryptophan, pyridoxine, and cyanocobalamin in tablets and oral suspension. </br> J AOAC Int. 2011 Nov-Dec;94(6):1785-90. PubMed PMID: 22320085. |
