Bufalin

• CAT Number: I003614
• CAS Number: 465-21-4
• Molecular Formula: C24H34O4
• Molecular Weight: 386.52
• Purity: ≥95%
• Synonyms: (3β,5β)-3,14-Dihydroxy-bufa-20,22-dienolide; 3β,14-dihydroxy-5β-Bufa-20,22-dienolide
• Target: Na+/K+ ATPase
• Solubility: DMSO: ≥ 31 mg/mL
• Storage: -20°C
• IUPAC Name: 5-[(3S,5R,8R,9S,10S,13R,14S,17R)-3,14-dihydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]pyran-2-one
• InChI: InChI=1S/C24H34O4/c1-22-10-7-17(25)13-16(22)4-5-20-19(22)8-11-23(2)18(9-12-24(20,23)27)15-3-6-21(26)28-14-15/h3,6,14,16-20,25,27H,4-5,7-13H2,1-2H3/t16-,17+,18-,19+,20-,22+,23-,24+/m1/s1
• InChIKey: QEEBRPGZBVVINN-BMPKRDENSA-N
• SMILES: CC12CCC(CC1CCC3C2CCC4(C3(CCC4C5=COC(=O)C=C5)O)C)O

Bufalin(CAT: I003614) is a naturally occurring bufadienolide compound found in the venom of certain species of toads, such as the Chinese toad (Bufo bufo gargarizans). It has been traditionally used in traditional Chinese medicine for its pharmacological effects. Bufalin exhibits various biological activities, including anticancer, anti-inflammatory, and cardiotoxic effects. It acts as a potent inhibitor of the Na+/K+-ATPase enzyme, which plays a crucial role in maintaining cellular ion balance. In addition, bufalin has been investigated for its potential as an anticancer agent due to its ability to induce cell cycle arrest and apoptosis in cancer cells.

Reference

[1]. Jiang L, et al. Bufalin induces cell cycle arrest and apoptosis in gallbladder carcinoma cells. Tumour Biol. 2014 Nov;35(11):10931-41. 

[2]. Wu SH, et al. Bufalin induces cell death in human lung cancer cells through disruption of DNA damage response pathways. Am J Chin Med. 2014;42(3):729-42. 

[3]. Rong X, et al. Bufalin, a bioactive component of the chinese medicine chansu, inhibits inflammation and invasion of human rheumatoid arthritis fibroblast-like synoviocytes. Inflammation. 2014 Aug;37(4):1050-8.

[4]. Yan S, et al. Bufalin enhances TRAIL-induced apoptosis by redistributing death receptors in lipid rafts in breast cancer cells. Anticancer Drugs. 2014 Jul;25(6):683-9. 

[5]. Wen L, et al. Anti-inflammatory and antinociceptive activities of bufalin in rodents. Mediators Inflamm. 2014;2014:171839.