Buformin Hydrochloride

For research use only. Not for therapeutic Use.

  • CAT Number: R008850
  • CAS Number: 1190-53-0
  • Molecular Formula: C6H16ClN5
  • Molecular Weight: 193.679
  • Purity: ≥95%
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Buformin is a biguanide derivative with antihyperglycemic activity. It delays absorption of glucose from the gastrointestinal tract, increases insulin sensitivity and glucose utilization in peripheral cells, and inhibits hepatic gluconeogenesis. It can also deactivate the glycolytic pathway by suppressing glyceraldehyde 3-phosphate dehydrogenase gene expression, which can lead to lactic acidosis. Biguanides, such as buformin, are reported to inhibit the mitochondrial respiratory complex I by inhibiting ubiquinone reduction and by stimulating reactive oxygen species production <em>via</em> the complex I flavin. Some biguanides, including buformin, can also inhibit the mitochondrial ATP synthase. Buformin has also been examined for antitumor activity due to its ability to disrupt the unfolded protein response transcription program during glucose deprivation, which induces cell death in glucose-deprived tumor cells.


Catalog Number R008850
CAS Number 1190-53-0
Synonyms

N-Butylidodicarbonimidic Diamide Hydrochloride; 1-Butylbiguanide Hydrochloride; 1-Butylbiguanide Hydrochloride; Buformine; Butformin; Butylbiguanide; Butyldiguanide; DBV; Dibetos B; Glybigid; Panformin; Sindiatil; Tidemol; Ziavetine;

Molecular Formula C6H16ClN5
Purity ≥95%
Target PI3K/Akt/mTOR
Storage -20°C
IUPAC Name 2-butyl-1-(diaminomethylidene)guanidine;hydrochloride
InChI InChI=1S/C6H15N5.ClH/c1-2-3-4-10-6(9)11-5(7)8;/h2-4H2,1H3,(H6,7,8,9,10,11);1H
InChIKey KKLWSPPIRBIEOV-UHFFFAOYSA-N
SMILES CCCCN=C(N)N=C(N)N.Cl

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