Bufotalin

• CAT Number: I003633
• CAS Number: 471-95-4
• Molecular Formula: C26H36O6
• Molecular Weight: 444.56
• Purity: ≥95%
• Solubility: DMSO: ≥ 4.6 mg/mL
• Storage: 3 years -20C powder

Bufotalin(CAT: I003633)is a naturally occurring cardiac glycoside that is derived from the venom of certain toad species, including Bufo bufo gargarizans and Bufo bufo gargarizans Cantor. It exhibits various pharmacological properties, including cardiotonic, anticancer, and antimicrobial effects. Bufotalin acts by inhibiting Na+/K+-ATPase, an enzyme responsible for maintaining the sodium and potassium ion balance in cells. By inhibiting this enzyme, bufotalin increases intracellular calcium levels, leading to enhanced cardiac contractility. Additionally, bufotalin has been studied for its potential anticancer activity, as it can induce apoptosis and inhibit cell proliferation in certain cancer cell lines. However, further research is needed to fully understand its mechanisms of action and potential therapeutic applications.

Reference

[1]. Zhu YR, et al. Bufotalin-induced apoptosis in osteoblastoma cells is associated with endoplasmic reticulum stress activation. Biochem Biophys Res Commun. 2014 Aug 15;451(1):112-8.
[2]. Zhang DM, et al. Bufotalin from Venenum Bufonis inhibits growth of multidrug resistant HepG2 cells through G2/M cell cycle arrest and apoptosis. Eur J Pharmacol. 2012 Oct 5;692(1-3):19-28.
[3]. Waiwut P, et al. Bufotalin sensitizes death receptor-induced apoptosis via Bid- and STAT1-dependent pathways. Int J Oncol. 2012 Jan;40(1):203-8.
[4]. Su CL, et al. Involvement of caspases and apoptosis-inducing factor in bufotalin-induced apoptosis of Hep 3B cells. J Agric Food Chem. 2009 Jan 14;57(1):55-61.