For research use only. Not for therapeutic Use.
Buntanetap ((+)-Phenserine) is a multiple neurotoxic protein translation inhibitor with oral activity, including amyloid precursor protein (APP), α-synuclein (αSYN) and huntingtin protein (HTT). Buntanetap has anti-inflammatory effects and can be used in the study of Alzheimer’s disease and Parkinson’s disease[1][2].
Buntanetap (1-25 μM; 24 h) significantly reduces the expression of APP, αSYN, and HTT in SH-SY5Y cells[2].
| Catalog Number | M134834 |
| CAS Number | 116839-68-0 |
| Synonyms | [(3aS,8bR)-3,4,8b-trimethyl-2,3a-dihydro-1H-pyrrolo[2,3-b]indol-7-yl] N-phenylcarbamate |
| Molecular Formula | C20H23N3O2 |
| Purity | ≥95% |
| InChI | InChI=1S/C20H23N3O2/c1-20-11-12-22(2)18(20)23(3)17-10-9-15(13-16(17)20)25-19(24)21-14-7-5-4-6-8-14/h4-10,13,18H,11-12H2,1-3H3,(H,21,24)/t18-,20+/m0/s1 |
| InChIKey | PBHFNBQPZCRWQP-AZUAARDMSA-N |
| SMILES | CC12CCN(C1N(C3=C2C=C(C=C3)OC(=O)NC4=CC=CC=C4)C)C |
| Reference | [1]. 1、 Fang C, et al. Buntanetap, a Novel Translational Inhibitor of Multiple Neurotoxic Proteins, Proves to Be Safe and Promising in Both Alzheimer’s and Parkinson’s Patients. J Prev Alzheimers Dis. 2023;10(1):25-33. [2]. 2、 Chen XQ, et al. Posiphen Reduces the Levels of Huntingtin Protein through Translation Suppression. Pharmaceutics. 2021 Dec 7;13(12):2109. |
