Butane-1,4-diyldiphosphonic acid

For research use only. Not for therapeutic Use.

  • CAT Number: I015611
  • CAS Number: 4671-77-6
  • Molecular Formula: C₄H₁₂O₆P₂
  • Molecular Weight: 218.08
  • Purity: ≥95%
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Butane-1,4-diyldiphosphonic acid(Cat No.:I015611) is an alkyl chain-based linker commonly used in the synthesis of proteolysis-targeting chimeras (PROTACs). It serves as a bridging molecule, connecting the target protein-ligand to the E3 ubiquitin ligase ligand. The alkyl chain provides the necessary flexibility and length for the proper positioning of the ligands, allowing for target protein degradation. By utilizing this linker, researchers can design and develop PROTAC molecules with enhanced efficacy in modulating protein levels and potentially treating various diseases by selectively degrading specific proteins within cells.


Catalog Number I015611
CAS Number 4671-77-6
Molecular Formula C₄H₁₂O₆P₂
Purity ≥95%
Target PROTAC Linkers
Reference

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

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