Butein

• CAT Number: I003720
• CAS Number: 487-52-5
• Molecular Formula: C15H12O5
• Molecular Weight: 272.3
• Purity: ≥95%
• Synonyms: (E)-1-(2,4-dihydroxyphenyl)-3-(3,4-dihydroxyphenyl)prop-2-en-1-one
• Target: EGFR
• Solubility: DMSO: ≥ 35 mg/mL
• Storage: 2-8°C
• InChI: InChI=1S/C15H12O5/c16-10-3-4-11(14(19)8-10)12(17)5-1-9-2-6-13(18)15(20)7-9/h1-8,16,18-20H/b5-1+
• InChIKey: AYMYWHCQALZEGT-ORCRQEGFSA-N
• SMILES: C1=CC(=C(C=C1C=CC(=O)C2=C(C=C(C=C2)O)O)O)O

Butein（Cat No.:I003720） is a plant polyphenol extracted from Rhus verniciflua, also known as the Japanese lacquer tree. It exhibits inhibitory effects on the activation of protein tyrosine kinase and the epidermal growth factor receptor (EGFR). By targeting these signaling pathways, butein has the potential to modulate cellular processes involved in cell growth, proliferation, and survival. Its ability to inhibit protein tyrosine kinase and EGFR activation makes it a promising compound for further investigation in the development of therapeutic strategies against diseases associated with dysregulated kinase signaling, such as cancer and inflammatory disorders.

Reference

[1]. Er-Bin Yang et al. Butein, a Specific Protein Tyrosine Kinase Inhibitor. Biochem Biophys Res Commun, 1998 Apr 17, 245(2):435-8.

[2]. Zhang L et al. Butein sensitizes HeLa cells to cisplatin through the AKT and ERK/p38 MAPK pathways by targeting FoxO3a. Int J Mol Med, 2015 Oct, 36(4):957-66

[3]. Hyeong Sim Choi et al. Rhus verniciflua Stokes (RVS) and butein induce apoptosis of paclitaxel-resistant SKOV-3/PAX ovarian cancer cells through inhibition of AKT phosphorylation. BMC Complement Altern Med, 2016, 16: 122.

[4]. Tang YL et al. Butein inhibits cell proliferation and induces cell cycle arrest in acute lymphoblastic leukemia via FOXO3a/p27kip1 pathway. Oncotarget, 2016 Apr 5, 7(14):18651-64.