For research use only. Not for therapeutic Use.
Butoconazole Nitrate（Cat No.:A001176）is an antifungal agent commonly used in the treatment of vaginal infections, such as yeast infections (vaginal candidiasis). As a synthetic imidazole derivative, Butoconazole Nitrate works by inhibiting the synthesis of ergosterol, a crucial component of fungal cell membranes, thereby disrupting their structure and function. This results in the inhibition of fungal growth and replication. Butoconazole Nitrate is typically formulated for topical application, ensuring targeted delivery to the affected area. It is recognized for its efficacy in treating uncomplicated yeast infections with minimal systemic side effects.
| Catalog Number | A001176 |
| CAS Number | 64872-77-1 |
| Synonyms | RS-35887 |
| Molecular Formula | C19H17Cl3N2S.HNO3 |
| Purity | ≥95% |
| Storage | Store at -20℃ |
| IUPAC Name | 1-[4-(4-chlorophenyl)-2-(2,6-dichlorophenyl)sulfanylbutyl]imidazole;nitric acid |
| InChI | InChI=1S/C19H17Cl3N2S.HNO3/c20-15-7-4-14(5-8-15)6-9-16(12-24-11-10-23-13-24)25-19-17(21)2-1-3-18(19)22;2-1(3)4/h1-5,7-8,10-11,13,16H,6,9,12H2;(H,2,3,4) |
| InChIKey | ZHPWRQIPPNZNML-UHFFFAOYSA-N |
| SMILES | C1=CC(=C(C(=C1)Cl)SC(CCC2=CC=C(C=C2)Cl)CN3C=CN=C3)Cl.[N+](=O)(O)[O-] |
| Reference | </br>1:Development of a liquid chromatography-tandem mass spectrometry method for determination of butoconazole nitrate in human plasma and its application to a pharmacokinetic study. Jia MM, Zhou Y, He XM, Wu YL, Li HQ, Chen H, Li WY.J Huazhong Univ Sci Technolog Med Sci. 2014 Jun;34(3):431-6. doi: 10.1007/s11596-014-1296-y. Epub 2014 Jun 18. PMID: 24939312 </br>2:[The statement of Polish Gynecological Society Experts on the treatment of acute vulvovaginal candidiasis with prolonged releasing 2% butoconazole nitrate vaginal cream–state of art in 2008]. Expert Board of Polish Gynecological Society..Ginekol Pol. 2009 Apr;80(4):303-11. Polish. PMID: 19507567 </br>3:An evaluation of butoconazole nitrate 2% site release vaginal cream (Gynazole-1) compared to fluconazole 150 mg tablets (Diflucan) in the time to relief of symptoms in patients with vulvovaginal candidiasis. Seidman LS, Skokos CK.Infect Dis Obstet Gynecol. 2005 Dec;13(4):197-206. PMID: 16338779 Free PMC Article</br>4:Butoconazole nitrate 2% for vulvovaginal candidiasis. New, single-dose vaginal cream formulation vs. seven-day treatment with miconazole nitrate. Gynazole 1 Study Group. Brown D, Henzl MR, Kaufman RH.J Reprod Med. 1999 Nov;44(11):933-8. PMID: 10589403 </br>5:Effect of butoconazole nitrate 2% vaginal cream and miconazole nitrate 2% vaginal cream treatments in patients with vulvovaginal candidiasis. Lappin MA, Brooker DC, Francisco CA, Dorfman J.Infect Dis Obstet Gynecol. 1996;4(6):323-8. PMID: 18476119 Free PMC Article</br>6:Vaginal retention of 2% butoconazole nitrate cream: comparison of a standard and a sustained-release preparation. Weinstein L, Henzel MR, Tsina IW.Clin Ther. 1994 Nov-Dec;16(6):930-4. PMID: 7697689 </br>7:Efficacy of butoconazole nitrate in the treatment of vulvo-vaginal candidiasis compared with clotrimazol and isoconasol. López Fiesco A, Ayala Ruíz A, Romo LM, Delgado MD, Zamora G.Proc West Pharmacol Soc. 1993;36:185-8. No abstract available. PMID: 8378376 </br>8:A comparison of butoconazole nitrate cream with econazole nitrate cream for the treatment of vulvovaginal candidiasis. Ruf H, Vitse M.J Int Med Res. 1990 Sep-Oct;18(5):389-99. PMID: 2257961 </br>9:Vulvovaginal candidosis: comparison of 3-day treatment with 2% butoconazole nitrate cream and 6-day treatment with 1% clotrimazole cream. Hajman AJ.J Int Med Res. 1988 Sep-Oct;16(5):367-75. PMID: 3197914 </br>10:[Butoconazole nitrate in vulvovaginal candidiasis. A comparative study with clotrimazole]. Herrera Nava E, Bervera Castañeda R, Escalona S, Gutiérrez M, Zamora López G.Ginecol Obstet Mex. 1988 May;56:138-43. Spanish. No abstract available. PMID: 3154229 |
