Butylphthalide

• CAT Number: I004286
• CAS Number: 6066-49-5
• Molecular Formula: C12H14O2
• Molecular Weight: 190.24
• Purity: ≥95%
• Target: Plants
• Solubility: 10mM in DMSO
• Storage: -20°C
• IUPAC Name: 3-butyl-3H-2-benzofuran-1-one
• InChI: InChI=1S/C12H14O2/c1-2-3-8-11-9-6-4-5-7-10(9)12(13)14-11/h4-7,11H,2-3,8H2,1H3
• InChIKey: HJXMNVQARNZTEE-UHFFFAOYSA-N
• SMILES: CCCCC1C2=CC=CC=C2C(=O)O1

Butylphthalide (Cat No.:I004286) is an organic compound. Also known as NBP (3-n-butylphthalide) or N-Butylphthalimide, it is derived from celery seeds. Butylphthalide exhibits various pharmacological activities, including antioxidant, anti-inflammatory, neuroprotective, and vasodilatory effects. It has shown potential in the treatment of neurological conditions such as ischemic stroke, Alzheimer’s disease, and vascular dementia. Additionally, it has been investigated for its cardiovascular benefits. Proper safety precautions should be followed when handling butylphthalide.

Reference

1:dl-3-n-butylphthalide promotes neuroplasticity and motor recovery in stroke rats. Sun Y, Cheng X, Wang H, Mu X, Liang Y, Luo Y, Qu H, Zhao C.Behav Brain Res. 2017 Apr 22;329:67-74. doi: 10.1016/j.bbr.2017.04.039. [Epub ahead of print] PMID: 28442357 2:Dl-3-n-butylphthalide improves functional recovery in rats with spinal cord injury by inhibiting endoplasmic reticulum stress-induced apoptosis. He Z, Zhou Y, Huang Y, Wang Q, Zheng B, Zhang H, Li J, Liu Y, Wu F, Zhang X, Tong S, Wang M, Wang Z, He H, Xu H, Xiao J.Am J Transl Res. 2017 Mar 15;9(3):1075-1087. eCollection 2017. PMID: 28386335 Free PMC Article3:DL-3-n-butylphthalide induced neuroprotection, regenerative repair, functional recovery and psychological benefits following traumatic brain injury in mice. Zhao Y, Lee JH, Chen D, Gu X, Caslin A, Li J, Yu SP, Wei L.Neurochem Int. 2017 Mar 28. pii: S0197-0186(17)30167-5. doi: 10.1016/j.neuint.2017.03.017. [Epub ahead of print] PMID: 28359729 4:Efficacy of N-Butylphthalide and Hyperbaric Oxygen Therapy on Cognitive Dysfunction in Patients with Delayed Encephalopathy After Acute Carbon Monoxide Poisoning. Xiang W, Xue H, Wang B, Li Y, Zhang J, Jiang C, Pang J.Med Sci Monit. 2017 Mar 29;23:1501-1506. PMID: 28352069 Free PMC Article5:Neuroprotective effect of Dl-3-n-butylphthalide on patients with radiation-induced brain injury: a clinical retrospective cohort study. Zhang X, Li Y, Li X, Rong X, Tang Y, Peng Y.Int J Neurosci. 2017 Apr 9:1-6. doi: 10.1080/00207454.2017.1310727. [Epub ahead of print] PMID: 28332424 6:Synthesis and biological evaluation of nitric oxide (NO)-hydrogen sulfide (H2S) releasing derivatives of (S)-3-n-butylphthalide as potential antiplatelet agents. Wang XL, Wang ZY, Ling JJ, Zhang YH, Yin J.Chin J Nat Med. 2016 Dec;14(12):946-953. doi: 10.1016/S1875-5364(17)30021-3. PMID: 28262123 7:N-Butylphthalide Improves Cognitive Function in Rats after Carbon Monoxide Poisoning. Bi MJ, Sun XN, Zou Y, Ding XY, Liu B, Zhang YH, Guo DD, Li Q.Front Pharmacol. 2017 Feb 9;8:64. doi: 10.3389/fphar.2017.00064. eCollection 2017. PMID: 28232802 Free PMC Article8:DL-3-n-Butylphthalide (NBP) Provides Neuroprotection in the Mice Models After Traumatic Brain Injury via Nrf2-ARE Signaling Pathway. Liu Z, Wang H, Shi X, Li L, Zhou M, Ding H, Yang Y, Li X, Ding K.Neurochem Res. 2017 May;42(5):1375-1386. doi: 10.1007/s11064-017-2186-z. Epub 2017 Feb 18. PMID: 28214984 9:Commentary: L-3-n-butylphthalide Rescues Hippocampal Synaptic Failure and Attenuates Neuropathology in Aged APP/PS1 Mouse Model of Alzheimer/’s Disease. Bhatt PC, Pandey P, Panda BP, Anwar F, Kumar V.Front Aging Neurosci. 2017 Jan 26;9:4. doi: 10.3389/fnagi.2017.00004. eCollection 2017. No abstract available. PMID: 28184195 Free PMC Article10:Dl-3-n-butylphthalide can improve the cognitive function of patients with acute ischemic stroke: a prospective intervention study. Yan H, Yan Z, Niu X, Wang J, Gui Y, Zhang P.Neurol Res. 2017 Apr;39(4):337-343. doi: 10.1080/01616412.2016.1268775. Epub 2017 Feb 1. PMID: 28145815