For research use only. Not for therapeutic Use.
Butyrolactone I(cas 87414-49-1) is one of a family of three butyrolactones isolated from Aspergillus fumigatus, first reported in 1983. Butyrolactone I exhibits antitumor activity, inhibiting the cell cycle at the G1/S and G2/M transitions. Butyrolactone I is a selective inhibitor of cyclin-dependent kinases CDK1/cyclin B, CDK2 and CDK5, and is an important bioprobe for understanding the cellular roles of CDKs.
| Catalog Number | R003808 |
| CAS Number | 87414-49-1 |
| Synonyms | (2R)-2,5-dihydro-4-hydroxy-2-[[4-hydroxy-3-(3-methyl-2-buten-1-yl)phenyl]methyl]-3-(4-hydroxyphenyl)-5-oxo-2-furancarboxylic acid, methyl ester |
| Molecular Formula | C₂₄H₂₄O₇ |
| Purity | 95% |
| Target | CDK |
| Appearance | Light yellow solid |
| Storage | -20°C |
| Analysis method | HPLC |
| IUPAC Name | [4-hydroxy-3-(3-methylbut-2-enyl)phenyl]methyl (2R)-4-hydroxy-3-(4-hydroxyphenyl)-2-methyl-5-oxofuran-2-carboxylate |
| InChI | InChI=1S/C24H24O7/c1-14(2)4-6-17-12-15(5-11-19(17)26)13-30-23(29)24(3)20(21(27)22(28)31-24)16-7-9-18(25)10-8-16/h4-5,7-12,25-27H,6,13H2,1-3H3/t24-/m1/s1 |
| InChIKey | FPVUCBMBMUHRDX-XMMPIXPASA-N |
| SMILES | CC(=CCC1=C(C=CC(=C1)COC(=O)C2(C(=C(C(=O)O2)O)C3=CC=C(C=C3)O)C)O)C |
| Reference | Metabolic products of Aspergillus terreus. IX. Biosynthesis of butyrolactone derivatives isolated from strains IFO 8835 and 4100. Nitta K. et al. Chem. Pharm. Bull. 1983, 31, 1528.<br /> |
