For research use only. Not for therapeutic Use.
BVDV-IN-1 is a non-nucleoside inhibitor (NNI) of bovine viral diarrhea virus (BVDV), with an EC50 of 1.8 μM. BVDV-IN-1 directly binds to a hydrophobic pocket of the BVDV RdRp. BVDV-IN-1 has antiviral activity against BVDV resistant to NNI thiosemicarbazone (TSC)[1].
BVDV-IN-1 (compound 1.9) binds to a hydrophobic pocket of the BVDV RNA-dependent RNA polymerase (RdRp)[1].
BVDV-IN-1 inhibits the replication of TSC-resistant BVDV variants in vitro[1].
| Catalog Number | I045424 |
| CAS Number | 345651-04-9 |
| Synonyms | 2-[4-(2-phenylquinazolin-4-yl)piperazin-1-yl]ethanol |
| Molecular Formula | C20H22N4O |
| Purity | ≥95% |
| InChI | InChI=1S/C20H22N4O/c25-15-14-23-10-12-24(13-11-23)20-17-8-4-5-9-18(17)21-19(22-20)16-6-2-1-3-7-16/h1-9,25H,10-15H2 |
| InChIKey | DPFKMYSBAMEGQK-UHFFFAOYSA-N |
| SMILES | C1CN(CCN1CCO)C2=NC(=NC3=CC=CC=C32)C4=CC=CC=C4 |
| Reference | [1]. Gabriela A Fernández, et al. Design and Optimization of Quinazoline Derivatives: New Non-nucleoside Inhibitors of Bovine Viral Diarrhea Virus. Front Chem. 2020 Dec 10;8:590235. |
