BVT-2733 Hydrochloride

• CAT Number: I012751
• CAS Number: 376641-65-5
• Molecular Formula: C17H22Cl2N4O3S2
• Molecular Weight: 465.4
• Purity: ≥95%
• Synonyms: BVT.2733; BVT2733; 3-chloro-2-methyl-N-[4-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]-1,3-thiazol- 2-yl]benzenesulfonamide hydrochloride
• IUPAC Name: 3-chloro-2-methyl-N-[4-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]-1,3-thiazol-2-yl]benzenesulfonamide;hydrochloride
• InChI: InChI=1S/C17H21ClN4O3S2.ClH/c1-12-14(18)4-3-5-15(12)27(24,25)20-17-19-13(11-26-17)10-16(23)22-8-6-21(2)7-9-22;/h3-5,11H,6-10H2,1-2H3,(H,19,20);1H
• InChIKey: VQQOVTXLJDVTLF-UHFFFAOYSA-N
• SMILES: CC1=C(C=CC=C1Cl)S(=O)(=O)NC2=NC(=CS2)CC(=O)N3CCN(CC3)C.Cl

BVT-2733 Hydrochloride (Cat.No:I012751) is a potent, selective, and reversible phosphodiesterase 4 (PDE4) inhibitor. It inhibits PDE4A, PDE4B, and PDE4D with IC50 values of 3.3 nM, 15.9 nM, and 26.2 nM, respectively. PDE4 inhibitors are being investigated as potential treatments for various inflammatory diseases such as asthma and chronic obstructive pulmonary disease. BVT-2733 Hydrochloride shows promising efficacy in preclinical studies for the treatment of asthma and other respiratory diseases.