For research use only. Not for therapeutic Use.
BVT 2733 (CAT: I003384) is a novel small molecule inhibitor that selectively targets the isoform 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1). This enzyme is involved in the interconversion of inactive cortisone to active cortisol in specific tissues. By inhibiting 11β-HSD1, BVT 2733 may modulate the local levels of cortisol, which could have implications for various physiological processes. The isoform-selective nature of BVT 2733 suggests that it may have potential applications in the treatment of conditions related to cortisol dysregulation, such as metabolic disorders and inflammation.
| Catalog Number | I003384 |
| CAS Number | 376640-41-4 |
| Synonyms | 3-chloro-2-methyl-N-(4-(2-(4-methylpiperazin-1-yl)-2-oxoethyl)thiazol-2-yl)benzenesulfonamide |
| Molecular Formula | C17H21ClN4O3S2 |
| Purity | ≥95% |
| Target | 11β-HSD |
| Solubility | DMSO:8mg/mL; |
| Storage | Store at -20°C |
| InChI | InChI=1S/C17H21ClN4O3S2/c1-12-14(18)4-3-5-15(12)27(24,25)20-17-19-13(11-26-17)10-16(23)22-8-6-21(2)7-9-22/h3-5,11H,6-10H2,1-2H3,(H,19,20) |
| InChIKey | YDPRNGAPPNPYQQ-UHFFFAOYSA-N |
| SMILES | ClC1=C(C)C(S(=O)(NC2=NC(CC(N3CCN(C)CC3)=O)=CS2)=O)=CC=C1 |
| Reference | </br>1:11β-Hydroxysteroid dehydrogenase type 1 selective inhibitor BVT.2733 protects osteoblasts against endogenous glucocorticoid induced dysfunction. Wu L, Qi H, Zhong Y, Lv S, Yu J, Liu J, Wang L, Bi J, Kong X, Di W, Zha J, Liu F, Ding G.Endocr J. 2013;60(9):1047-58. Epub 2013 Jun 12. PMID: 23759754 Free Article</br>2:BVT.2733, a selective 11β-hydroxysteroid dehydrogenase type 1 inhibitor, attenuates obesity and inflammation in diet-induced obese mice. Wang L, Liu J, Zhang A, Cheng P, Zhang X, Lv S, Wu L, Yu J, Di W, Zha J, Kong X, Qi H, Zhong Y, Ding G.PLoS One. 2012;7(7):e40056. doi: 10.1371/journal.pone.0040056. Epub 2012 Jul 2. PMID: 22768329 Free PMC Article</br>3:[Mechanism of BVT.2733 and pioglitazone in the improvement of insulin resistance]. Xie Y, Zhu T, Zhong Y, Liu J, Yu J, Zha JM, DI WJ, Ding GX.Zhonghua Nei Ke Za Zhi. 2008 Nov;47(11):938-41. Chinese. PMID: 19080239 |
