For research use only. Not for therapeutic Use.
BW 755C is a 5-lipoxygenase (5-LO) inhibitor with an IC50 of 5 μM. BW 755C also inhibits cyclooxygenase (COX) with IC50s of 0.65 and 1.2 μg/mL against COX-1 and COX-2, respectively[1][2].
BW 755C (0.03-10 mg/rat; s.c.; once) inhibits the ovulation rate and ovarian levels of 5-HETE and 12-HETE in rats[3].
| Catalog Number | R065062 |
| CAS Number | 66000-40-6 |
| Synonyms | 2-[3-(trifluoromethyl)phenyl]-3,4-dihydropyrazol-5-amine |
| Molecular Formula | C10H10F3N3 |
| Purity | ≥95% |
| InChI | InChI=1S/C10H10F3N3/c11-10(12,13)7-2-1-3-8(6-7)16-5-4-9(14)15-16/h1-3,6H,4-5H2,(H2,14,15) |
| InChIKey | CPXGGWXJNQSFEP-UHFFFAOYSA-N |
| SMILES | C1CN(N=C1N)C2=CC=CC(=C2)C(F)(F)F |
| Reference | [1]. Hlasta DJ, et al. 5-Lipoxygenase inhibitors: the synthesis and structure-activity relationships of a series of 1-phenyl-3-pyrazolidinones. J Med Chem. 1991 May;34(5):1560-70. [2]. Mitchell JA, et al. Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase. Proc Natl Acad Sci U S A. 1993 Dec 15;90(24):11693-7. [3]. Tanaka N, et al. Comparison of inhibitory actions of indomethacin and epostane on ovulation in rats. Am J Physiol. 1991 Feb;260(2 Pt 1):E170-4. |
