BW-A 78U

• CAT Number: M004452
• CAS Number: 101155-02-6
• Molecular Formula: C13H12FN5
• Molecular Weight: 257.27
• Purity: ≥95%
• Synonyms: 9-[(2-fluorophenyl)methyl]-N-methylpurin-6-amine
• InChI: InChI=1S/C13H12FN5/c1-15-12-11-13(17-7-16-12)19(8-18-11)6-9-4-2-3-5-10(9)14/h2-5,7-8H,6H2,1H3,(H,15,16,17)
• InChIKey: MZABAGHILOTTOD-UHFFFAOYSA-N
• SMILES: CNC1=C2C(=NC=N1)N(C=N2)CC3=CC=CC=C3F

BW-A 78U is a PDE4 inhibitor with an IC50 of 3 μM.
BW-A 78U is a PDE4 inhibitor with an IC50 of 3 μM. BW-A 78U fails to significantly inhibit arachidonate release. BW-A 78U is ineffective to inhibit the lipopolysaccharide (LPS)-induced TNF-α release[1].

Reference

[1]. Boichot E, et al. Anti-inflammatory activities of a new series of selective phosphodiesterase 4 inhibitors derivedfrom 9-benzyladenine. J Pharmacol Exp Ther. 2000 Feb;292(2):647-53.
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