For research use only. Not for therapeutic Use.
BWA868C is a DP receptor-selective antagonist. It reverses the anti-aggregatory effects of DP receptor agonists in a dose-dependent manner. Likewise, BW A868C antagonizes the accumulation of cAMP in rabbit non-pigmented ciliary epithelial cells. The Ki for BW A868C is approximately 1.7 nM.
| Catalog Number | M017319 |
| CAS Number | 118675-50-6 |
| Synonyms | 3-[(2-cyclohexyl-2-hydroxyethyl)amino]-2,5-dioxo-1-(phenylmethyl)-4-imidazolidineheptanoic acid |
| Molecular Formula | C25H37N3O5 |
| Purity | ≥95% |
| Target | Prostaglandin Receptor |
| Solubility | Soluble in DMSO |
| Storage | Store at -20°C |
| IUPAC Name | 7-[1-benzyl-3-[(2-cyclohexyl-2-hydroxyethyl)amino]-2,5-dioxoimidazolidin-4-yl]heptanoic acid |
| InChI | InChI=1S/C25H37N3O5/c29-22(20-13-7-4-8-14-20)17-26-28-21(15-9-1-2-10-16-23(30)31)24(32)27(25(28)33)18-19-11-5-3-6-12-19/h3,5-6,11-12,20-22,26,29H,1-2,4,7-10,13-18H2,(H,30,31) |
| InChIKey | YZJVWSKJHGEIBL-UHFFFAOYSA-N |
| SMILES | C1CCC(CC1)C(CNN2C(C(=O)N(C2=O)CC3=CC=CC=C3)CCCCCCC(=O)O)O |
| Reference | </br>1:Interaction of BW A868C, a prostanoid DP-receptor antagonist, with two receptor subtypes in the rabbit isolated saphenous vein. Lydford SJ, McKechnie KC, Leff P.Prostaglandins. 1996 Aug;52(2):125-39. Erratum in: Prostaglandins 1997 Jan;53(1):59-62. PMID: 8880898 </br>2:Partial agonist effects of BW A868C, a selective DP receptor antagonist, on Cl- secretion in dog tracheal epithelium. Liu YJ, Jackson DM, Blackham A, Leff P.Eur J Pharmacol. 1996 May 23;304(1-3):117-22. PMID: 8813592 </br>3:Effects of BW A868C, a selective prostaglandin DP receptor antagonist, in dog isolated vascular preparations. Liu YJ, Jackson DM, Blackham A.Eur J Pharmacol. 1996 May 15;303(3):187-92. PMID: 8813566 </br>4:Effects of a selective DP receptor agonist (BW 245C) and antagonist (BW A868C) on the canine colonic epithelium: an argument for a different DP receptor? Rangachari PK, Betti PA, Prior ET, Roberts LJ 2nd.J Pharmacol Exp Ther. 1995 Nov;275(2):611-7. PMID: 7473146 </br>5:The role of prostanoid TP- and DP-receptors in the bronchoconstrictor effect of inhaled PGD2 in anaesthetized guinea-pigs: effect of the DP-antagonist BW A868C. Hamid-Bloomfield S, Payne AN, Petrovic AA, Whittle BJ.Br J Pharmacol. 1990 Aug;100(4):761-6. PMID: 2119842 Free PMC Article</br>6:The classification of prostaglandin DP-receptors in platelets and vasculature using BW A868C, a novel, selective and potent competitive antagonist. Giles H, Leff P, Bolofo ML, Kelly MG, Robertson AD.Br J Pharmacol. 1989 Feb;96(2):291-300. PMID: 2924081 Free PMC Article</br>7:Antagonism of PGD2 vasodepressor responses in the rat in vivo by the novel, selective antagonist, BW A868C. Hamid-Bloomfield S, Whittle BJ.Br J Pharmacol. 1989 Feb;96(2):307-12. PMID: 2647205 Free PMC Article</br>8:The antagonism by BW A868C of PGD2 and BW245C activation of human platelet adenylate cyclase. Trist DG, Collins BA, Wood J, Kelly MG, Robertson AD.Br J Pharmacol. 1989 Feb;96(2):301-6. PMID: 2466517 Free PMC Article |
