For research use only. Not for therapeutic Use.
The hydrochloride salt form of BX 795 (Axon 1390), which was initially developed as a PDPK1 inhibitor. Recent study highlighted on its bioactivitiy as a potent and relatively specific inhibitor of TBK1 and closely related IKKε, with IC50 values to be 6, 41, and 111 nM for TBK1, IKKε and PDPK1 respectively.
KEYWORDS: BX 795 hydrochloride | supplier | PDK1/TBK1 inhibitor | BX795 hydrochloride | BX-795 hydrochloride | CAS [1472611-45-2] | [702675-74-9] | Phosphatidylinositol | IKK | PDPK | TBK | Inhibitor | Enzymes
| Catalog Number | I023890 |
| CAS Number | 1472611-45-2 |
| Molecular Formula | C23H26IN7O2S.HCl |
| Purity | ≥95% |
| IUPAC Name | N-[3-[[5-iodo-4-[3-(thiophene-2-carbonylamino)propylamino]pyrimidin-2-yl]amino]phenyl]pyrrolidine-1-carboxamide;hydrochloride |
| InChI | InChI=1S/C23H26IN7O2S.ClH/c24-18-15-27-22(30-20(18)25-9-5-10-26-21(32)19-8-4-13-34-19)28-16-6-3-7-17(14-16)29-23(33)31-11-1-2-12-31;/h3-4,6-8,13-15H,1-2,5,9-12H2,(H,26,32)(H,29,33)(H2,25,27,28,30);1H |
| SMILES | C1CCN(C1)C(=O)NC2=CC=CC(=C2)NC3=NC=C(C(=N3)NCCCNC(=O)C4=CC=CS4)I.Cl |
| Reference | R I Feldman et al. Novel Small Molecule Inhibitors of 3-Phosphoinositide-dependent Kinase-1. J. Biol. Chem., 2005, 280, 20, 19867-19874. J Bain et al. The selectivity of protein kinase inhibitors: a further update. Biochem. J. 2007, 408, 297–315. C Peifer, D R. Alessi, Small-Molecule Inhibitors of PDK1. ChemMedChem. 2008, 3 (12), 1810–1838. K Clark et al. Use of the pharmacological inhibitor BX795 to study the regulation and physiological roles of TBK1 and IκB kinase ϵ: a distinct upstream kinase mediates SER-172 phosphoylation and activation. J. Biol. Chem. 2009, 284, 14136-14146. |
