BX471 hydrochloride

• CAT Number: I002991
• CAS Number: 288262-96-4
• Molecular Formula: C21H25Cl2FN4O3
• Molecular Weight: 471.35
• Purity: ≥95%
• Target: CCR1
• Solubility: 10 mM in DMSO
• Storage: Store at -20℃
• IC50: 1 nM(Ki) [1]
• IUPAC Name: [5-chloro-2-[2-[(2R)-4-[(4-fluorophenyl)methyl]-2-methylpiperazin-1-yl]-2-oxoethoxy]phenyl]urea;hydrochloride
• InChI: InChI=1S/C21H24ClFN4O3.ClH/c1-14-11-26(12-15-2-5-17(23)6-3-15)8-9-27(14)20(28)13-30-19-7-4-16(22)10-18(19)25-21(24)29;/h2-7,10,14H,8-9,11-13H2,1H3,(H3,24,25,29);1H/t14-;/m1./s1
• InChIKey: FRUCNQBAWUHKLS-PFEQFJNWSA-N
• SMILES: C[C@@H]1CN(CCN1C(=O)COC2=C(C=C(C=C2)Cl)NC(=O)N)CC3=CC=C(C=C3)F.Cl

BX471 hydrochloride (Cat.No:I002991) is a potent and selective antagonist of C-C motif chemokine receptor 1 (CCR1). It binds specifically to the receptor and inhibits its activation by its ligands, such as CCL3 and CCL5. BX471 has been shown to reduce the infiltration of inflammatory cells in animal models of various diseases, including arthritis and multiple sclerosis. It may have potential as a therapeutic agent for inflammatory disorders.

Reference

[1]. Furuichi K, et al. Chemokine receptor CCR1 regulates inflammatory cell infiltration after renal ischemia-reperfusion injury. J Immunol. 2008 Dec 15;181(12):8670-6.
[2]. Liang M, et al. Identification and characterization of a potent, selective, and orally active antagonist of the CC chemokine receptor-1. J Biol Chem. 2000 Jun 23;275(25):19000-8.
[3]. Anders HJ, et al. A chemokine receptor CCR-1 antagonist reduces renal fibrosis after unilateral ureter ligation. J Clin Invest. 2002 Jan;109(2):251-9.