BX471

• CAT Number: I002664
• CAS Number: 217645-70-0
• Molecular Formula: C21H24ClFN4O3
• Molecular Weight: 434.9
• Purity: ≥95%
• Synonyms: (R)-1-(5-chloro-2-(2-(4-(4-fluorobenzyl)-2-methylpiperazin-1-yl)-2-oxoethoxy)phenyl)urea
• Target: Immunology/Inflammation
• Solubility: DMSO: ≥ 51 mg/mL
• Storage: Store at +4C
• IC50: 1 nM(Ki) [1]
• InChIKey: XQYASZNUFDVMFH-CQSZACIVSA-N

BX471(CAT: I002664) is a potent and selective non-peptide antagonist of the chemokine receptor CCR1. It inhibits the binding of chemokines to CCR1, thereby blocking the activation of CCR1 signaling pathways. CCR1 is a G-protein coupled receptor involved in the migration and activation of immune cells, particularly monocytes and T cells. By selectively targeting CCR1, BX471 has the potential to modulate immune responses and inflammation. It may have applications in the treatment of various inflammatory and autoimmune diseases where CCR1 signaling plays a role.

Reference

[1]. Liang M, et al. Identification and characterization of a potent, selective, and orally active antagonist of the CC chemokine receptor-1. J Biol Chem. 2000 Jun 23;275(25):19000-8.
[2]. Anders HJ, et al. A chemokine receptor CCR-1 antagonist reduces renal fibrosis after unilateral ureter ligation. J Clin Invest. 2002 Jan;109(2):251-9.
[3]. Furuichi K, et al. Chemokine receptor CCR1 regulates inflammatory cell infiltration after renal ischemia-reperfusion injury. J Immunol. 2008 Dec 15;181(12):8670-6.