For research use only. Not for therapeutic Use.
C-176(CAT: I019711) is a potent covalent inhibitor of mouse STING (stimulator of interferon genes). It strongly inhibits STING-mediated IFNβ reporter activity, specifically targeting the STING pathway and not affecting RIG-I- or TBK1-mediated activities. Treatment with C-176 significantly reduces the induction of serum levels of type I interferons (IFNs) and IL-6 mediated by cyclic GMP-AMP (cGAMP) synthase (cGAS)/STING-dependent pathway, indicating its ability to modulate the immune response. These findings suggest that C-176 may have potential applications in the study of immune signaling pathways and inflammatory diseases where STING activation is implicated.
| Catalog Number | I019711 |
| CAS Number | 314054-00-7 |
| Molecular Formula | C₁₁H₇IN₂O₄ |
| Purity | ≥95% |
| Target | STING |
| Reference | [1]. Haag SM, et al. Targeting STING with covalent small-molecule inhibitors. Nature. 2018 Jul;559(7713):269-273. |
