For research use only. Not for therapeutic Use.
C-7280948 is a selective and potent protein methyltransferase1 (PRMT1) inhibitor with an IC50 value of 12.75 μM[1].
C-7280948 is compound 6a in this article, it against hPRMT1 with an IC50 value of 12.75 μM.Especially arginine methyltransferases also target non-histone protein substrates and are therefore often called protein methyltransferases (PRMTs).The subtype PRMT1 has been linked to the activation of estrogen and androgen receptors and therefore may represent a new treatment option for hormone-dependent cancer.
| Catalog Number | I004200 |
| CAS Number | 587850-67-7 |
| Synonyms | 4-amino-N-(2-phenylethyl)benzenesulfonamide |
| Molecular Formula | C14H16N2O2S |
| Purity | ≥95% |
| InChI | InChI=1S/C14H16N2O2S/c15-13-6-8-14(9-7-13)19(17,18)16-11-10-12-4-2-1-3-5-12/h1-9,16H,10-11,15H2 |
| InChIKey | BYWZPUPRVIECEC-UHFFFAOYSA-N |
| SMILES | C1=CC=C(C=C1)CCNS(=O)(=O)C2=CC=C(C=C2)N |
| Reference | [1]. Bissinger EM, et al. Acyl derivatives of p-aminosulfonamides and dapsone as new inhibitors of the arginine methyltransferase hPRMT1. Bioorg Med Chem. 2011 Jun 15;19(12):3717-3731. |
