C-82

• CAT Number: I023930
• CAS Number: 1422253-37-9
• Molecular Formula: C33H34N6O4
• Molecular Weight: 578.67
• Purity: 98%
• Synonyms: C-82; C 82; C82
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
• IUPAC Name: (6S,9S,9aS)-N-benzyl-6-(4-hydroxybenzyl)-2,9-dimethyl-4,7-dioxo-8-(quinolin-8-ylmethyl)hexahydro-2H-pyrazino[2,1-c][1,2,4]triazine-1(6H)-carboxamide
• InChI: InChI=1S/C33H34N6O4/c1-22-31-38(29(41)21-36(2)39(31)33(43)35-19-24-8-4-3-5-9-24)28(18-23-13-15-27(40)16-14-23)32(42)37(22)20-26-11-6-10-25-12-7-17-34-30(25)26/h3-17,22,28,31,40H,18-21H2,1-2H3,(H,35,43)/t22-,28-,31-/m0/s1
• InChIKey: KLGHKOORFHZFGO-AZXNYEMZSA-N
• SMILES: O=C(N1N(C)CC(N([C@H]2CC3=CC=C(O)C=C3)[C@]1([H])[C@H](C)N(CC4=CC=CC5=C4N=CC=C5)C2=O)=O)NCC6=CC=CC=C6

C-82 is a potent and selective small molecule inhibitor of heat shock protein 90 (HSP90), a chaperone protein involved in stabilizing client proteins required for tumor cell survival. By binding to the ATP-binding site of HSP90, C-82 disrupts its chaperone activity, leading to the degradation of oncogenic client proteins. This mechanism of action makes C-82 a promising candidate for cancer therapy, especially in targeting cancers that are dependent on HSP90 for the maintenance of key signaling pathways.