For research use only. Not for therapeutic Use.
C 87 is a selective and potent inhibitor of sphingosine kinase 1 (SphK1), a key enzyme in the sphingolipid signaling pathway. By blocking SphK1 activity, C 87 reduces the production of sphingosine-1-phosphate (S1P), a bioactive lipid involved in cell survival, proliferation, and angiogenesis. This inhibition makes C 87 a valuable tool in cancer research, as it can suppress tumor growth and metastasis. Additionally, it is utilized in studies exploring inflammatory and immune-related diseases, emphasizing its importance in therapeutic development and cellular signaling research.
| Catalog Number | I011215 |
| CAS Number | 332420-90-3 |
| Synonyms | 3-Phenyl-1-(4-phenyl-2-thiazolyl)-1H-pyrazole-4,5-dione 4-[2-(4-chloro-3-nitrophenyl)hydrazone] |
| Molecular Formula | C24H15ClN6O3S |
| Purity | ≥95% |
| Solubility | Soluble to 20 mM in DMSO |
| Storage | Store at +4C |
| IUPAC Name | 4-[(4-chloro-3-nitrophenyl)diazenyl]-5-phenyl-2-(4-phenyl-1,3-thiazol-2-yl)-1H-pyrazol-3-one |
| InChI | 1S/C24H15ClN6O3S/c25-18-12-11-17(13-20(18)31(33)34)27-28-22-21(16-9-5-2-6-10-16)29-30(23(22)32)24-26-19(14-35-24)15-7-3-1-4-8-15/h1-14,29H |
| InChIKey | HTEQQWJUYYUNQG-UHFFFAOYSA-N |
| SMILES | C1=CC=C(C=C1)C2=CSC(=N2)N3C(=O)C(=C(N3)C4=CC=CC=C4)N=NC5=CC(=C(C=C5)Cl)[N+](=O)[O-] |
