C-Type Natriuretic Peptide (CNP) (1-22), human TFA

• CAT Number: I044324
• CAS Number: 1966153-17-2
• Molecular Formula: C95H158F3N27O30S3
• Molecular Weight: 2311.62
• Purity: ≥95%

C-Type Natriuretic Peptide (CNP) (1-22), human (TFA),a 1-22 fragment of CNP, is a natriuretic peptide receptor B (NPR-B) agonist. C-Type Natriuretic Peptide (CNP) (1-22), human (TFA) inhibits cAMP synthesis stimulated by the physiological agonists histamine and 5-HT or directly by Forskolin. CNP is a potent, endothelial-derived relaxant and growthinhibitory factor[1][2][3].
C-Type Natriuretic Peptide (CNP) (1-22), human (TFA) (0.01, 0.1, 1, 10, 100, 1000 nM) increases cGMP production in CHO cells expressing human NPR-B in a concentration-dependent manner[1].
PK parameters of CNP immunoreactivity after a single intravenous administration of C-Type Natriuretic Peptide (CNP) (1-22), human[1]:

Dose(nM/kg)
AUC0-∞(pM·min/mL)
MRT0-∞(min)
T1/2(min)
CLtot(mL/min/kg)
Vdss(mL/kg)

20
320±54
1.02±0.18
1.42±0.45
63.9±11.9
64.2±5.1

PK parameters of CNP immunoreactivity after a single subcutaneous administration of C-Type Natriuretic Peptide (CNP) (1-22), human[1]:

Dose(nM/kg)
Cmax(pM/mL)
Tmax(min)
AUC0-∞(pM·min/mL)
MRT0-∞(min)
T1/2(min)
BA(%)

50
9.02±3.74
5.0±0.0
152±73
13.9±3.4
10.0±5.0
19±9

Each value represents the mean±SD of 3 rats. MRT=mean residence time, CLtot=total clearance, T1/2=half-life period, BA=bioavailability.
i.c.v. administration of C-Type Natriuretic Peptide (CNP) (1-22) in a dose of 2 nM induces an increase in the severity of picrotoxin-kindled convulsions 24 and 48 hrs after application of the peptide[3].

Reference

[1]. Morozumi N, et al. ASB20123: A novel C-type natriuretic peptide derivative for treatment of growth failure and dwarfism. PLoS One. 2019 Feb 22;14(2):e0212680.
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[2]. Buckley MG, et al. Circulating C-type natriuretic peptide is increased in orthotopic cardiac transplant recipients and associated with cardiac allograft vasculopathy. Clin Sci (Lond). 2000 Nov;99(5):467-72.
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[3]. Mazarati AM, et al. ANP(1-28), BNP(1-32) and CNP(1-22) increase the severity of picrotoxin-kindled seizure syndrome in rats. Life Sci. 1993;52(3):PL19-24.
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