For research use only. Not for therapeutic Use.
C101248 is a first potent and selective inhibitor of THIK-1 with an IC50 value of 50 nM. Moreover, C101248 was inactive against K2P family members TREK-1 and TWIK-2, and Kv2.1.
KEYWORDS: C101248 | Supplier | THIK-1 inhibitor | C-101248 | C 101248 | CAS [361368-24-3] | Potassium
| Catalog Number | I047728 |
| CAS Number | 361368-24-3 |
| Molecular Formula | C15H12N6O |
| Purity | ≥95% |
| IUPAC Name | 4-[1-(pyridin-4-ylmethyl)benzimidazol-2-yl]-1,2,5-oxadiazol-3-amine |
| InChI | InChI=1S/C15H12N6O/c16-14-13(19-22-20-14)15-18-11-3-1-2-4-12(11)21(15)9-10-5-7-17-8-6-10/h1-8H,9H2,(H2,16,20) |
| SMILES | C1=CC=C2C(=C1)N=C(N2CC3=CC=NC=C3)C4=NON=C4N |
| Reference | B Ossola et al. Characterisation of C101248: A novel selective THIK-1 channel inhibitor for the modulation of microglial NLRP3-inflammasome. Neuropharmacology. 2023 Feb 15;0(0):109330. |
