C108297(CAT: I005361) is a selective glucocorticoid receptor (GR) modulator with a high binding affinity (GR binding Ki 0.7 nM; GR reporter gene functional Ki 0.6 nM). It has been studied for its potential to attenuate obesity by reducing caloric intake, promoting lipolysis, and increasing fat oxidation. In addition to its metabolic effects, C108297 also exhibits anti-inflammatory properties, making it a compound of interest in the treatment of conditions that involve both metabolic dysfunction and inflammation. Its selective action on the glucocorticoid receptor makes it a promising candidate for therapeutic development in metabolic and inflammatory diseases.
| Catalog Number | I005361 |
| CAS Number | 864972-30-5 |
| Synonyms | (4aR)-6-(4-tert-butylphenyl)sulfonyl-1-(4-fluorophenyl)-4a-(2-methoxyethoxymethyl)-4,5,7,8-tetrahydropyrazolo[3,4-g]isoquinoline |
| Molecular Formula | C30H36FN3O4S |
| Purity | % |
| InChI | InChI=1S/C30H36FN3O4S/c1-29(2,3)23-5-11-27(12-6-23)39(35,36)33-14-13-24-17-28-22(18-30(24,20-33)21-38-16-15-37-4)19-32-34(28)26-9-7-25(31)8-10-26/h5-12,17,19H,13-16,18,20-21H2,1-4H3/t30-/m1/s1 |
| InChIKey | OMKDFVUMRKROMY-SSEXGKCCSA-N |
| SMILES | CC(C)(C)C1=CC=C(C=C1)S(=O)(=O)N2CCC3=CC4=C(CC3(C2)COCCOC)C=NN4C5=CC=C(C=C5)F |
