For research use only. Not for therapeutic Use.
C188（Cat No.:I009336）is a small molecule inhibitor that targets the Janus kinase (JAK) family of enzymes, specifically JAK2, which is involved in the signaling of various cytokine receptors. By inhibiting JAK2, C188 can interfere with the downstream signaling pathways that contribute to inflammation, immune cell activation, and cancer cell growth. It has shown potential in preclinical studies for the treatment of diseases such as rheumatoid arthritis and certain cancers, including hematologic malignancies. Further clinical trials are necessary to assess its safety, efficacy, and therapeutic applications in these conditions.
| Catalog Number | I009336 |
| CAS Number | 823828-18-8 |
| Synonyms | C188; C-188; C 188; STAT3-IN-C188; Cpd188; Cpd-188; Cpd 188;;4-(3-Carboxymethylsulfanyl-4-hydroxy-naphthalen-1-ylsulfamoyl)-benzoic acid |
| Molecular Formula | C19H15NO7S2 |
| Purity | ≥95% |
| Target | Stem Cell/Wnt |
| Solubility | Soluble in DMSO |
| Storage | Store at 0-8 °C |
| IUPAC Name | 4-[[3-(carboxymethylsulfanyl)-4-hydroxynaphthalen-1-yl]sulfamoyl]benzoic acid |
| InChI | InChI=1S/C19H15NO7S2/c21-17(22)10-28-16-9-15(13-3-1-2-4-14(13)18(16)23)20-29(26,27)12-7-5-11(6-8-12)19(24)25/h1-9,20,23H,10H2,(H,21,22)(H,24,25) |
| InChIKey | CIERPRDYPKVDJO-UHFFFAOYSA-N |
| SMILES | C1=CC=C2C(=C1)C(=CC(=C2O)SCC(=O)O)NS(=O)(=O)C3=CC=C(C=C3)C(=O)O |
