For research use only. Not for therapeutic Use.
C215 is a potent inhibitor of MmpL3. C215 is identified in HTS with glycerol independent activity against M. tuberculosis, limited non-specific toxicity against mammalian cells, an IC90 of 16 μM against M. tuberculosis, and efficacy against M. tuberculosis growing in macrophages[1].
| Catalog Number | I012396 |
| CAS Number | 912780-51-9 |
| Synonyms | N-[(2,4-dichlorophenyl)methyl]-1-propylbenzimidazol-5-amine |
| Molecular Formula | C17H17Cl2N3 |
| Purity | ≥95% |
| InChI | InChI=1S/C17H17Cl2N3/c1-2-7-22-11-21-16-9-14(5-6-17(16)22)20-10-12-3-4-13(18)8-15(12)19/h3-6,8-9,11,20H,2,7,10H2,1H3 |
| InChIKey | PWEPSIFNTIQCNN-UHFFFAOYSA-N |
| SMILES | CCCN1C=NC2=C1C=CC(=C2)NCC3=C(C=C(C=C3)Cl)Cl |
| Reference | [1]. Stanley SA, Grant SS, Kawate T, et al. Identification of novel inhibitors of M. tuberculosis growth using whole cell based high-throughput screening. ACS Chem Biol. 2012;7(8):1377-1384. |
