For research use only. Not for therapeutic Use.
Production of ceramide occurs upon hydrolysis of sphingomyelin by a specific isoform of PLC, appropriately named sphingomyelinase. Lignoceric ceramide (C24:0) is one of the most abundant naturally occurring ceramides. Ceramides mediate many diverse biological activities, as has been demonstrated in studies utilizing cell-<wbr></wbr>permeable ceramide analogs. A few of the processes regulated by ceramides include apoptosis, cell differentiation, proliferation of smooth muscle cells, and inhibition of the mitochondrial respiratory chain.
| Catalog Number | R001317 |
| CAS Number | 34435-05-7 |
| Synonyms | Lignoceric Ceramide |
| Molecular Formula | C42H83NO3 |
| Purity | ≥95% |
| Target | Liposome |
| Storage | -20°C |
| InChIKey | ZJVVOYPTFQEGPH-GLIYQNSVSA-N |
| Reference | <br>1. J. M. Hauser, B. M. Buehrer, and R. M. Bell “Role of ceramide in mitogenesis induced by exogenous sphingoid bases.” Journal of Biological ChemistryVol. 269 pp. 6803, 1994<br>2. N. S. Radin, “Killing tumours by ceramide-induced apoptosis: a critique of available drugs” Biochemical Journal, Vol. 371 pp. 243-256, 2003<br>3. N. S. Radin, “Designing anticancer drugs via the achilles heel: ceramide, allylic ketones, and mitochondria” Bioorganic and Medicinal Chemistry, Vol.11(10) pp. 2123-2142, 2003</br></br></br> |
