For research use only. Not for therapeutic Use.
C24:1-Ceramide is one of the most abundant naturally occurring ceramide. Ceramides regulates many diverse biological activities, such as cell apoptosis, cell differentiation, proliferation of smooth muscle cells, and inhibition of the mitochondrial respiratory chain[1][2][3].
C24:1-Ceramide can bind to phospho–Tyr-216-GSK3 (pYGSK3)[4].
C24:1-Ceramide (1 μM, 48 h) induces elongation of cilia in ependymal cells[4].
| Catalog Number | R001070 |
| CAS Number | 54164-50-0 |
| Synonyms | (Z)-N-[(E,2S,3R)-1,3-dihydroxyoctadec-4-en-2-yl]tetracos-15-enamide |
| Molecular Formula | C42H81NO3 |
| Purity | ≥95% |
| InChI | InChI=1S/C42H81NO3/c1-3-5-7-9-11-13-15-17-18-19-20-21-22-23-24-26-28-30-32-34-36-38-42(46)43-40(39-44)41(45)37-35-33-31-29-27-25-16-14-12-10-8-6-4-2/h17-18,35,37,40-41,44-45H,3-16,19-34,36,38-39H2,1-2H3,(H,43,46)/b18-17-,37-35+/t40-,41+/m0/s1 |
| InChIKey | VJSBNBBOSZJDKB-KPEYJIHVSA-N |
| SMILES | CCCCCCCCCCCCCC=CC(C(CO)NC(=O)CCCCCCCCCCCCCC=CCCCCCCCC)O |
| Reference | [1]. Gudz, T.I., et al. Direct inhibition of mitochondrial respiratory chain complex III by cell-permeable ceramide. The Journal of Biological Chemisty 272(39), 24154-24158 (1997). [2]. ugé, N., et al. The sphingomyelin-ceramide signaling pathway is involved in oxidized low density lipoprotein-induced cell proliferation. The Journal of Biological Chemisty 271(32), 19251-19255 (1996). [3]. Gu, Q., et al. Ceramide profiling of complex lipid mixtures by electrospray ionization mass spectrometry. Anal. Biochem. 244(2), 347-356 (1997). [4]. Kong JN, et al. Regulation of Chlamydomonas flagella and ependymal cell motile cilia by ceramide-mediated translocation of GSK3. Mol Biol Cell. 2015 Dec 1;26(24):4451-65. |
