C25-140

• CAT Number: I019180
• CAS Number: 1358099-18-9
• Molecular Formula: C₂₆H₃₁N₇O
• Molecular Weight: 457.57
• Purity: ≥95%
• Storage: Store at -20°C
• IUPAC Name: 1-(4-benzylpiperidin-1-yl)-3-[3,5-dimethyl-1-(3-methyl-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)pyrazol-4-yl]propan-1-one
• InChI: InChI=1S/C26H31N7O/c1-18-23(19(2)32(29-18)25-11-10-24-28-27-20(3)33(24)30-25)9-12-26(34)31-15-13-22(14-16-31)17-21-7-5-4-6-8-21/h4-8,10-11,22H,9,12-17H2,1-3H3
• InChIKey: HFKVRXVHZGBRKF-UHFFFAOYSA-N
• SMILES: CC1=C(C(=NN1C2=NN3C(=NN=C3C=C2)C)C)CCC(=O)N4CCC(CC4)CC5=CC=CC=C5

C25-140（Cat No.:I019180） is a small molecule that inhibits the interaction between TRAF6 and Ubc13. By directly binding to TRAF6, C25-140 prevents the interaction between TRAF6 and Ubc13, leading to reduced TRAF6 activity. Additionally, C25-140 has been shown to block NF-κB activation in various immune and inflammatory signaling pathways in human and murine primary cells.

Reference

[1]. Brenke JK, et al. Targeting TRAF6 E3 ligase activity with a small-molecule inhibitor combats autoimmunity. J Biol Chem. 2018 Aug 24;293(34):13191-13203.