For research use only. Not for therapeutic Use.
C646（Cat No.:I013849）is a selective inhibitor of histone acetyltransferase (HAT), particularly targeting the p300/CBP family of enzymes. By inhibiting these enzymes, C646 disrupts the acetylation of histones and non-histone proteins, influencing gene expression and cellular processes. This compound has shown potential in cancer research, as it can suppress tumor growth and promote apoptosis in various cancer cell lines by re-establishing transcriptional repression of oncogenes. Additionally, C646’s specificity for HATs makes it a valuable tool for studying the role of acetylation in epigenetic regulation and disease mechanisms.
| Catalog Number | I013849 |
| CAS Number | 328968-36-1 |
| Molecular Formula | C₂₄H₁₉N₃O₆ |
| Purity | ≥95% |
| Target | Histone Acetyltransferase; Autophagy; Epigenetic Reader Domain; Apoptosis |
| Solubility | DMSO: ≥ 36 mg/mL |
| IUPAC Name | 4-[(4Z)-4-[[5-(4,5-dimethyl-2-nitrophenyl)furan-2-yl]methylidene]-3-methyl-5-oxopyrazol-1-yl]benzoic acid |
| InChI | InChI=1S/C24H19N3O6/c1-13-10-20(21(27(31)32)11-14(13)2)22-9-8-18(33-22)12-19-15(3)25-26(23(19)28)17-6-4-16(5-7-17)24(29)30/h4-12H,1-3H3,(H,29,30)/b19-12- |
| InChIKey | HEKJYZZSCQBJGB-UNOMPAQXSA-N |
| SMILES | CC1=CC(=C(C=C1C)[N+](=O)[O-])C2=CC=C(O2)/C=C\3/C(=NN(C3=O)C4=CC=C(C=C4)C(=O)O)C |
| Reference | [1]. Bowers EM, et al. Virtual ligand screening of the p300/CBP histone acetyltransferase: identification of a selective small molecule inhibitor. Chem Biol. 2010 May 28;17(5):471-82.<br>[2]. Oike T, et al. C646, a selective small molecule inhibitor of histone acetyltransferase p300, radiosensitizes lung cancer cells by enhancing mitotic catastrophe. Radiother Oncol. 2014 May;111(2):222-7.<br>[3]. Zheng WW, et al. EDAG positively regulates erythroid differentiation and modifies GATA1 acetylation through recruiting p300. Stem Cells. 2014 Aug;32(8):2278-89. |
