Caerulomycin

• CAT Number: R005968
• CAS Number: 21802-37-9
• PubChem Substance ID: 135514797
• Molecular Formula: C12H11N3O2
• Molecular Weight: 229.20
• Purity: 98%
• Target: Fungal
• Appearance: White solid
• Storage: -20°C
• Analysis method: HPLC
• IUPAC Name: (NE)-N-[(4-methoxy-6-pyridin-2-ylpyridin-2-yl)methylidene]hydroxylamine
• InChI: InChI=1S/C12H11N3O2/c1-17-10-6-9(8-14-16)15-12(7-10)11-4-2-3-5-13-11/h2-8,16H,1H3/b14-8+
• InChIKey: JCTRJRHLGOKMCF-RIYZIHGNSA-N
• SMILES: COC1=CC(=NC(=C1)C2=CC=CC=N2)/C=N/O

Caerulomycin（Cat No.:R005968）is a blue-colored antibiotic and immunosuppressive natural product originally isolated from the soil bacterium Streptomyces caeruleus. Structurally, it is a 2,2′-bipyridine derivative that can bind metals and function as a siderophore. Caerulomycin exhibits antimicrobial activity against various bacteria and fungi, and also demonstrates immunosuppressive properties, potentially acting by modulating cytokine production and inhibiting specific immune cell activities. Research suggests it may have therapeutic potential in conditions requiring immune modulation or antimicrobial intervention. 

Reference

Caerulomycin, a new antibiotic from Streptomyces caeruleus Baldacci: I. Production, isolation, assay and biological properties. Funk A. & Divekar P.V. Can. J. Microbiol. 1959, 5, 317.

Caerulomycin, a new antibiotic from Streptomyces caeruleus Baldacci. II. Structure. Divekar P.V. et al. Can. J. Chem. 1967, 45, 1215.