For research use only. Not for therapeutic Use.
Calcimycin（Cat No.:I010380）, also known as A23187, is an ionophore antibiotic that selectively transports divalent cations like calcium (Ca²⁺) across biological membranes. Commonly used in biochemical research, it helps study calcium signaling pathways by enabling controlled increases in intracellular calcium levels, crucial for understanding processes like muscle contraction, neurotransmitter release, and cell signaling. Calcimycin’s unique ability to alter calcium dynamics also makes it valuable in investigating apoptosis and other calcium-dependent mechanisms. Though primarily a research tool, it has been influential in advancing cell biology and pharmacology studies.
| Catalog Number | I010380 |
| CAS Number | 52665-69-7 |
| Synonyms | Calcimycin |
| Molecular Formula | C29H37N3O6 |
| Purity | 99% |
| Target | Bacterial; Fungal; Apoptosis; Autophagy; Antibiotic |
| Solubility | Soluble to 50 mM in DMSO |
| Appearance | White Powder |
| Storage | Desiccate at +4C |
| Analysis method | HPLC |
| IUPAC Name | 5-(methylamino)-2-[[(2S,3R,5R,6S,8R,9R)-3,5,9-trimethyl-2-[(2S)-1-oxo-1-(1H-pyrrol-2-yl)propan-2-yl]-1,7-dioxaspiro[5.5]undecan-8-yl]methyl]-1,3-benzoxazole-4-carboxylic acid |
| InChI | InChI=1S/C29H37N3O6/c1-15-10-11-29(17(3)13-16(2)27(38-29)18(4)26(33)20-7-6-12-31-20)37-22(15)14-23-32-25-21(36-23)9-8-19(30-5)24(25)28(34)35/h6-9,12,15-18,22,27,30-31H,10-11,13-14H2,1-5H3,(H,34,35)/t15-,16-,17-,18-,22-,27+,29+/m1/s1 |
| InChIKey | HIYAVKIYRIFSCZ-CYEMHPAKSA-N |
| SMILES | C[C@@H]1CC[C@]2([C@@H](C[C@H]([C@H](O2)[C@H](C)C(=O)C3=CC=CN3)C)C)O[C@@H]1CC4=NC5=C(O4)C=CC(=C5C(=O)O)NC |
| Reference | Structure of A23187, a divalent cation ionophore. Chaney M. O. et al. JACS 1974, 96, 1932.<br /> |
