For research use only. Not for therapeutic Use.
Calcipotriol (hydrate) is a low-<wbr></wbr>calcemic vitamin D receptor (VDR) agonist. Calcipotriol (hydrate) is about 200 times less potent in its effects on calcium metabolism than vitamin D (1,25[OH]D<sub>3</sub>). Binding of calcipotriol (hydrate) to the VDR increases AP-<wbr></wbr>1, a transcription factor important for keratinocyte differentiation, and reduces expression of JunB protein, a transcriptional activator in the inflammatory response. Calcipotriol (hydrate) also induces expression of thymic stromal lymphopoietin, which triggers T-<wbr></wbr>cell differentiation in keratinocytes.
| Catalog Number | M026875 |
| CAS Number | 112828-00-9 |
| Synonyms | Calcipotriene |
| Molecular Formula | C27H40O3 · H2O |
| Purity | ≥95% |
| Storage | -20°C |
| InChIKey | XBKHACNRWFKJNC-MANNPBRJSA-N |
