Calcitonin Gene Related Peptide (CGRP) II, rat TFA

• CAT Number: I046114
• Molecular Formula: C163H267N51O50S2.xC2HF3O2
• Molecular Weight: 3805.31 (free base)
• Purity: ≥95%

Calcitonin Gene Related Peptide (CGRP) II, rat TFA, a CGRP receptor activator, is a potent and long-lasting vasodilator. Calcitonin Gene Related Peptide (CGRP) II TFA can be used in the research of cardiovascular diseases[1].
Calcitonin Gene Related Peptide (CGRP) II, rat TFA induces vasodilator effects in small-diameter pig left anterior descending (LAD) coronary arteries with an EC50 value of 0.56 nM[1].
Calcitonin Gene Related Peptide (CGRP) II, rat TFA relaxes the spontaneous tone in isolated internal anal sphincter (IAS) strips, with an EC50 value of 83 μM[2].
Calcitonin Gene Related Peptide (CGRP) II, rat TFA (rβCGRP) inhibits [125I]hαCGRP binding (IC50: 7 nM), and stimulates cAMP accumulation (EC50: 0.56 nM) in the cells co-expressing mRAMP1 (mouse receptor-activity-modifying-protein 1) and rCRLR (rat calcitonin receptor-like receptor)[3].
Calcitonin Gene Related Peptide (CGRP) II, rat TFA (rat-βCGRP, 0.01-100 nM) induces endothelium-independent relaxations in the coronary arteries from male and female Sprague-Dawley rats, with an IC50 value of 2.8 nM approximately[4].
Calcitonin Gene Related Peptide (CGRP) II, rat TFA (rat-βCGRP, bolus injection, 0.3 μg/kg, at 10 min intervals) induces hypotension and vasodilatation in Male Sprague-Dawley rats[5].

Reference

[1]. D Wu, et al. Development and potential of non-peptide antagonists for calcitonin-gene-related peptide (CGRP) receptors: evidence for CGRP receptor heterogeneity. Biochem Soc Trans. 2002 Aug;30(4):468-73.
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[2]. F M Wisskirchen, et al. CGRP(2) receptor in the internal anal sphincter of the rat: implications for CGRP receptor classification. Br J Pharmacol. 2000 May;130(2):464-70.
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[3]. K Husmann, et al. Mouse receptor-activity-modifying proteins 1, -2 and -3: amino acid sequence, expression and function. Mol Cell Endocrinol. 2000 Apr 25;162(1-2):35-43.
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[4]. M Sheykhzade, et al. Characterization of calcitonin gene-related peptide (CGRP) receptors in intramural coronary arteries from male and female Sprague Dawley rats. Br J Pharmacol. 1998 Apr;123(7):1464-70.
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[5]. Kenneth A Petersen, et al. Inhibitory effect of BIBN4096BS on cephalic vasodilatation induced by CGRP or transcranial electrical stimulation in the rat. Br J Pharmacol. 2004 Nov;143(6):697-704.
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