Calcium influx inducer compound 634

• CAT Number: I047714
• CAS Number: 882291-37-4
• Molecular Formula: C15H15N3O4S3
• Molecular Weight: 397.49
• Purity: ≥95%
• IUPAC Name: ethyl 2-(2,1,3-benzothiadiazol-4-ylsulfonylamino)-4,5-dimethylthiophene-3-carboxylate
• InChI: InChI=1S/C15H15N3O4S3/c1-4-22-15(19)12-8(2)9(3)23-14(12)18-25(20,21)11-7-5-6-10-13(11)17-24-16-10/h5-7,18H,4H2,1-3H3
• SMILES: CCOC(=O)C1=C(SC(=C1C)C)NS(=O)(=O)C2=CC=CC3=NSN=C32

Calcium influx inducer compound 634 enhanced the release of extracellular vesicles (EVs) with immunostimulatory potency via induction of Ca2+ influx. Moreover, compound 634 enhanced the number of EVs released by murine bone marrow-derived dendritic cells (mBMDCs) and increased costimulatory molecule expression on parental mBMDCs in a SOCE-dependent manner.
Keywords: Calcium influx inducer compound 634 | Supplier | Ca influx inducer | CAS [882291-37-4] | Calcium | Non Selective | Inducer | Ion Channels | Immune studies | Vaccine | Innate immunity | ISRE | EV-based vaccine | Store-operated Ca2+ entry | SOCE

Reference

Y Sako et al. Identification of a Novel Small Molecule That Enhances the Release of Extracellular Vesicles with Immunostimulatory Potency via Induction of Calcium Influx. ACS Chem Biol. 2023 Apr 21;18(4):982-993.