Calcium Levofolinate

• CAT Number: A000889
• CAS Number: 80433-71-2
• Molecular Formula: C20H21N7O7.Ca
• Molecular Weight: 511.50
• Purity: ≥95%
• Synonyms: Calcium Folinate
• Target: Antifolate
• Storage: -20°C
• IUPAC Name: calcium;(2S)-2-[[4-[[(6S)-2-amino-5-formyl-4-oxo-3,6,7,8-tetrahydropteridin-6-yl]methylamino]benzoyl]amino]pentanedioate
• InChI: InChI=1S/C20H23N7O7.Ca/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30;/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32);/q;+2/p-2/t12-,13-;/m0./s1
• InChIKey: KVUAALJSMIVURS-QNTKWALQSA-L
• SMILES: C1[C@@H](N(C2=C(N1)N=C(NC2=O)N)C=O)CNC3=CC=C(C=C3)C(=O)N[C@@H](CCC(=O)[O-])C(=O)[O-].[Ca+2]

Calcium Levofolinate（Cat No.:A000889）, also known as leucovorin calcium, is the calcium salt form of folinic acid, a derivative of folic acid. It is used in combination with chemotherapeutic agents like methotrexate to reduce toxicity or enhance the efficacy of drugs like 5-fluorouracil (5-FU) in cancer treatment. Calcium Levofolinate rescues normal cells from the toxic effects of methotrexate by replenishing folate stores, thereby protecting healthy cells during chemotherapy. It also enhances 5-FU’s effectiveness by stabilizing the bond between 5-FU and thymidylate synthase, amplifying its anticancer activity.