Calmodulin antagonist-1

• CAT Number: R020469
• CAS Number: 78957-84-3
• Molecular Formula: C14H18Cl2N2O2S
• Molecular Weight: 349.28
• Purity: ≥95%
• Synonyms: N-(4-aminobutyl)-5-chloronaphthalene-1-sulfonamide;hydrochloride
• InChI: InChI=1S/C14H17ClN2O2S.ClH/c15-13-7-3-6-12-11(13)5-4-8-14(12)20(18,19)17-10-2-1-9-16;/h3-8,17H,1-2,9-10,16H2;1H
• InChIKey: IKMXJMNRHREPOD-UHFFFAOYSA-N
• SMILES: C1=CC2=C(C=CC=C2Cl)C(=C1)S(=O)(=O)NCCCCN.Cl

Calmodulin antagonist-1 (A-5) is a calmodulin (CaM) antagonist. Calmodulin antagonist-1 inhibits calmodulin-activated Ca2+-phosphodiesterase (PDE) (IC50=66 μM). Calmodulin antagonist-1 also inhibits trypsin-treated Ca2+-PDE (IC50=560 μM) in a competitive fashion with respect to cyclic GMP[1].

Reference

[1]. Itoh H, et al. Direct interaction of calmodulin antagonists with Ca2+/calmodulin-dependent cyclic nucleotide phosphodiesterase. J Biochem. 1984;96(6):1721-1726.
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